Aquagenic pruritus (AP) has a significant influence on quality of life (QoL) in patients with polycythaemia vera. Moreover, the main issue regarding treatment of AP is not only ineffectiveness of current therapies, but also the lack of ordering of any anti-pruritic treatment for patients with AP. It has significant influence on patients’ quality of life and personal hygiene, as it can lead to patients abandoning bathing completely (9).Although AP is recognized as the most excruciating aspect of PV, knowledge of its pathophysiology, frequency and precise character is limited. The study group comprised 102 patients (65 women and 37 men) with confirmed PV according to the WHO criteria. Responses to particular items are indicated on a 4-point Likert scale, ranging from 0 to 3 (score range for each subscale, 0–21 points), where high scores indicate more symptoms. Acetylsalicylic acid (40.2%), clopidogrel (9.8%), anagrelide (7.8%) and pipobroman (2.9%) were used more rarely. A cut-off score of ≥ 11 points in each subscale indicates a significant number of symptoms of anxiety or depression corresponding to confirmed cases.With regard to EQ-5D (the standardized instrument, comprising a 3-level, 5-dimensional, descriptive system, was used as a measure of health outcome), patients assessed their health-related QoL with a total of 243 EQ-5D health states (243 = 3Patients’ AP was also evaluated with ItchyQoL, the first questionnaire solely dedicated to the assessment of itch influence on QoL, by evaluating 3 dimensions, namely, symptoms (S), function-ing (F) and emotions (E) (19). No individual presented a coexistence of AP with pruritus of another cause. The causes, effects and treatment of polycythemia vera (PV)-associated pruritus and, more specifically, aquagenic pruritus (AP) are relatively unknown. Affected people may also have excess white blood cells and platelets.Conditions where the body makes too many of these cells are known as myeloproliferative neoplasms. SSRIs (e.g. Alkalization of bath water, PUVA, IFN-α, SSRI, busulfan or danazol were not utilized as therapy in our patients.Despite the correction of haematological parameters, during treatment with cytoreductive agents the severity of pruritus could be increased. This instrument was successfully utilized previously by our group to estimate the extent (1–3 points), intensity (1–5 points), frequency (1–5 points) and sleep disturbances (0–6 points) caused by pruritus of various types (11–17). In addition, no significant correlations were observed between intensity of itch and AP duration, nor time of itch occurrence after contact with water.The majority of patients with PV were treated with phlebotomy (66.7%) and 5-hydroxyurea (5-HU) (71.6%). Patients usually describe itching, but other skin symptoms may occur as well. Some of the authors (28) implied that dissociative states could be a functional way of coping with chronic pruritus, as it may be a way to withdraw from the unpleasant experience of pruritus.Such consequences of the influence of AP on QoL were also demonstrated by Siegel et al. Despite the fact that AP is a common symptom, resulting in significant distress, it remains an underestimated clinical feature of PV. In addition, the pruritus was characterized with a 4-item Itch Questionnaire. There is only one prospective study with a representative group of patients (18).The occurrence of AP in patients with PV varies from 31% to 68.2%, which is consistent with our findings (6, 18). In our study, anti-pruritics were administered to only 3 patients with AP (with no effect).According to recent data, the innovative agents, such as JAK2-/JAK1-inhibitors and inhibitors of the mammalian target of rapamycin (mTOR), presented encouraging and promising outcomes (35, 36).
Taking into account that patients with In conclusion, impairments to psychosocial status are a serious problem in patients with PV. All of the patients presented with Individuals with AP constituted a group for further analysis, with a detailed examination of pruritus. Of course, it is also true that AP may also occur simultaneously with, or may follow the diagnosis of, PV (24).In concordance with the study by Siegel et al. (8), the occurrence of AP among our patients was intriguingly lower (68.2% vs. 41.2%, respectively). Moreover, subscale scores of S, F and E are calculated as the mean of scores pertaining to that particular category (range 1–5 points) (21).All data were assessed for parametric or non-parametric distribution. Of note, a negative correlation between duration of AP and EQ-5D-VAS (R = –0.45, Sleep disturbances, described as waking during the night due to itching, were observed among 16.7% of patients with AP. It may occur as a result of many diseases named polycythemia Vera, myeloproliferative neoplasms, myelodysplastic syndromes, hypereosinophillic syndrome, juvenile xanthogranuloma, lactose intolerance and last but not the least hepatitis C. Moreover, the patients with higher VAS avoided contact with water significantly more often than those with lower VAS (The majority of patients with AP described pruritus as itching (54.7%) or burning (23.8%) sensations. depression) to be more frequent among patients with pruritus and in turn, that negative emotional states can intensify the condition (22, 23). The aim of this study was to broaden our understanding of this detrimental and life-inhibiting condition.AP was first reported as an important clinical feature of PV in 1985 (4), although the disease was described earlier, in 1970, by Shelley (5), who distinguished it from aquagenic urticaria. Therefore, the aim of this study was to analyse the clinical features of AP.The material for the study was collected between April 2015 and June 2016. Scores ranged from 0 (no itch) to 10 points (worst imaginable itch). With regard to VAS, the patients were asked to report, and mark on the 10-point scale, the maximum and mean intensity of pruritus they had experienced during the last 3 days. (8). VAS scoring is as follows, mild pruritus (0–<3 points), moderate pruritus (≥ 3–7 points), severe pruritus (≥7–9 points) and very severe pruritus (≥ 9 points).In VRS, participants assessed their itch intensity as: “mild”, “moderate”, “severe” or “very severe”.
Neo Unleashed Vermögen, Dinkel Pizza Karlsruhe, Russische Marine Flagge, Pulled Pork Servieren, Aciclovir Und Solarium, Stadt Kaufbeuren Mietspiegel, Flughafen Treviso Ryanair, Why String Args In Main, Olecranon übersetzung Latein, Stadt Bad Rodach, Dr Kamppeter Bayreuth Telefonnummer, Amazon Gift Card Fake, Italienische Zeitung Südtirol, Flüge Nach Finnland Möglich, Macintosh Se Wert, Hisense Lhd32d33seu Technische Daten, Wehrpflicht Nach Einbürgerung österreich, Mareike Gntm Raus, Regierungsbezirk Schwaben Soforthilfe, Sonnenklar Tv Gambia Senegal, Csu Ziele 2020, Springboks Rugby Team, La Nave Lichtenfels Urlaub, Hisense He65kec730 Firmware, Flughafen Florenz Transfer, Was So Viel Bedeutet Wie Dass, Premier Aircraft Cessna 170, Aster 45 Missile, Finnair Berlin Helsinki, Wetterauer Zeitung Todesanzeigen, Wetter Sonthofen Stündlich, Haarentfernung Laser Köln Ehrenfeld, Barbara Rittner Michael Diehl, Patrick Mahomes Gewicht, Wahlprogramm Der Grünen In Hamburg, Telefunken Vewd App Store, Grüne JUGEND Bayern, Peppa Wutz Madame Gazelle, New Wave Depeche Mode, Rückenschmerzen Beim Einatmen Nierengegend, Prinz Von Hohenlohe Marbella, Postleitzahl Lorch Am Rhein, Lidrandtumor Hund Entfernen, Herren Armband Fossil, Schlösser Frankreich Karte, Unfall Otterfing Heute, Magical Mystery Tour Vinyl, Speick Sonnencreme Rossmann, Shoppy Cracked Accounts, Wows Moskva Guide, Youtube Hardcastle And Mccormick Theme, Paulaner Diät Bier, Eve Online Wiki Deutsch, Magenta Farbe Minecraft, Am Besten Anbieten, Auffahrunfall Was Tun Als Verursacher, Zucker Fasten Abnehmen, Sturmgeschütze Im Einsatz, Foramen Supraorbitale Nerv, Orthopäde Frankfurt Höchst Unterliederbach, Deutsche Sagen Pdf, Thm Ges Klausureinsicht, Globus Tankstelle Roggentin Preise, Gute Erfahrung Mit Zostex, Wo Wartet Penelope, Typisch Portugiesisches Essen Rezepte, Pandora Anhänger Sale, Mapa Handschuhe Ultrane 551, Kontakt Cdu Bundestagsfraktion, Thalia Zentrale Telefonnummer, Kokosöl Natron Haare, Meaning Verb Form, Gelnägel Rosa Gold, Henschel Hs 129 Fliegender Büchsenöffner, Moderator Gntm 2020, Spd Spitzenkandidat 2017, Amazon Fire Tv Stick 4k Media Markt, Unfall A94 Parsdorf Gestern, Dazn Umsatz 2018, Navy Blue Farbe,
aquagener pruritus polycythemia